Fred Poordad Selected Research

Ritonavir (Norvir)

5/2019	Ombitasvir/paritaprevir/ritonavir + dasabuvir +/- ribavirin in real world hepatitis C patients.
1/2019	Efficacy and safety of ombitasvir/paritaprevir/ritonavir and dasabuvir with low-dose ribavirin in patients with chronic hepatitis C virus genotype 1a infection without cirrhosis.
1/2019	Ombitasvir/paritaprevir/ritonavir and dasabuvir with or without sofosbuvir for patients with hepatitis C virus genotype 1 infection who failed a prior course of direct-acting antiviral therapy.
10/2017	Safety of the 2D/3D direct-acting antiviral regimen in HCV-induced Child-Pugh A cirrhosis - A pooled analysis.
2/2016	Sustained virologic response of 100% in HCV genotype 1b patients with cirrhosis receiving ombitasvir/paritaprevir/r and dasabuvir for 12weeks.
1/2016	High antiviral activity of NS5A inhibitor ABT-530 with paritaprevir/ritonavir and ribavirin against hepatitis C virus genotype 3 infection.
11/2015	Ombitasvir/paritaprevir/r, dasabuvir and ribavirin for cirrhotic HCV patients with thrombocytopaenia and hypoalbuminaemia.
2/2015	Low relapse rate leads to high concordance of sustained virologic response (SVR) at 12 weeks with SVR at 24 weeks after treatment with ABT-450/ritonavir, ombitasvir, and dasabuvir plus ribavirin in subjects with chronic hepatitis C virus genotype 1 infection in the AVIATOR study.
2/2015	Exploratory trial of ombitasvir and ABT-450/r with or without ribavirin for HCV genotype 1, 2, and 3 infection.
5/2014	ABT-450/r-ombitasvir and dasabuvir with ribavirin for hepatitis C with cirrhosis.

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Fred Poordad Research Topics

Disease

57	Infections 10/2020 - 11/2003
33	Chronic Hepatitis C 01/2019 - 10/2007
30	Fibrosis (Cirrhosis) 01/2022 - 09/2012
15	Hepatitis C 06/2019 - 11/2003
12	Liver Diseases (Liver Disease) 06/2020 - 06/2008
7	Anemia 01/2017 - 10/2010
5	Non-alcoholic Fatty Liver Disease 11/2020 - 11/2003
5	Thrombocytopenia (Thrombopenia) 04/2020 - 06/2008
4	Fatigue 05/2019 - 08/2010
3	Portal Hypertension 06/2020 - 11/2015
3	Persistent Infection 09/2011 - 03/2011
2	Hemorrhage 01/2020 - 01/2011
2	Diarrhea 05/2019 - 01/2017
2	Nausea 01/2017 - 01/2010
2	Body Weight (Weight, Body) 05/2014 - 01/2014
2	Chronic Hepatitis B 05/2014 - 02/2010
2	Hepatitis B 06/2013 - 02/2010
2	Hemolytic Anemia 02/2012 - 10/2010
1	Acute Kidney Injury (Acute Renal Failure) 01/2021
1	Hepatorenal Syndrome 01/2021
1	Chronic Renal Insufficiency 10/2019
1	Overweight 10/2019
1	Sleep Initiation and Maintenance Disorders (Insomnia) 05/2019
1	Headache (Headaches) 05/2019
1	Biliary Liver Cirrhosis (Primary Biliary Cirrhosis) 01/2019
1	Prediabetic State (Prediabetes) 07/2018
1	Bronchitis 01/2017
1	Gastroenteritis 01/2017
1	Disease Progression 01/2017
1	Pruritus (Itching) 01/2017
1	Pneumonia (Pneumonitis) 01/2017
1	Obesity 01/2016

Drug/Important Bio-Agent (IBA)

54	Ribavirin (Virazole)FDA LinkGeneric 10/2019 - 11/2003
21	Antiviral Agents (Antivirals)IBA 01/2022 - 06/2008
21	InterferonsIBA 01/2018 - 11/2003
13	paritaprevirIBA 05/2019 - 01/2013
13	Protease Inhibitors (Protease Inhibitor)IBA 01/2018 - 03/2011
13	N- (3- amino- 1- (cyclobutylmethyl)- 2,3- dioxopropyl)- 3- (2- ((((1,1- dimethylethyl)amino)carbonyl)amino)- 3,3- dimethyl- 1- oxobutyl)- 6,6- dimethyl- 3- azabicyclo(3.1.0)hexan- 2- carboxamideIBA 05/2014 - 03/2011
12	Ritonavir (Norvir)FDA Link 05/2019 - 01/2013
10	ombitasvirIBA 05/2019 - 01/2014
10	dasabuvirIBA 05/2019 - 01/2013
8	SofosbuvirIBA 06/2020 - 03/2015
7	glecaprevir and pibrentasvirIBA 10/2020 - 01/2017
6	daclatasvirIBA 06/2020 - 05/2015
5	Biomarkers (Surrogate Marker)IBA 01/2022 - 11/2015
5	pibrentasvirIBA 10/2019 - 01/2016
5	Pharmaceutical PreparationsIBA 05/2019 - 08/2010
4	SimeprevirIBA 06/2020 - 12/2013
4	glecaprevirIBA 10/2019 - 10/2016
4	Interferon-alpha (Interferon Alfa)IBA 02/2012 - 01/2008
3	Alanine Transaminase (SGPT)IBA 10/2019 - 01/2013
3	RNA (Ribonucleic Acid)IBA 05/2019 - 01/2008
3	peginterferon alfa-2b (Pegintron)FDA Link 05/2014 - 01/2013
3	telaprevirIBA 04/2014 - 03/2011
3	Erythropoietin FDA Link 11/2013 - 03/2011
3	EnzymesIBA 02/2011 - 11/2003
2	Aspartate Aminotransferases (Aspartate Transaminase)IBA 11/2020 - 10/2019
2	grazoprevirIBA 01/2019 - 01/2017
2	elbasvirIBA 01/2019 - 01/2017
2	Proteins (Proteins, Gene)FDA Link 01/2017 - 05/2015
2	asunaprevirIBA 05/2015 - 05/2015
2	8- cyclohexyl- N- ((dimethylamino)sulfonyl)- 1,1a,2,12b- tetrahydro- 11- methoxy- 1a- ((3- methyl- 3,8- diazabicyclo(3.2.1)oct- 8- yl)carbonyl)cycloprop(d)indolo(2,1- a)(2)benzazepine- 5- carboxamideIBA 05/2015 - 05/2015
2	Interferon alpha-2 (Roferon-A)FDA Link 08/2014 - 12/2009
2	Hepatitis B e AntigensIBA 05/2014 - 02/2010
2	Emtricitabine (Emtriva)FDA Link 05/2014 - 06/2013
2	eltrombopag FDA Link 02/2014 - 06/2008
2	Hemoglobins (Hemoglobin)IBA 03/2013 - 01/2013
1	Small Interfering RNA (siRNA)IBA 01/2022
1	Messenger RNA (mRNA)IBA 01/2022
1	CollagenIBA 01/2022
1	HSP47 Heat-Shock Proteins (Heat Shock Protein 47)IBA 01/2022
1	Lipid NanoparticlesIBA 01/2022
1	TerlipressinIBA 01/2021
1	P-300IBA 10/2020
1	avatrombopagIBA 01/2020
1	Triglycerides (Triacylglycerol)IBA 10/2019
1	Drug CombinationsIBA 01/2019
1	Complement System Proteins (Complement)IBA 01/2019
1	uprifosbuvirIBA 01/2019
1	ruzasvirIBA 01/2019
1	SaltsIBA 01/2019
1	ledipasvirIBA 01/2019
1	QuartzIBA 01/2019
1	Acetyl-CoA CarboxylaseIBA 12/2018
1	firsocostatIBA 12/2018
1	Insulin (Novolin)FDA Link 07/2018
1	TabletsIBA 01/2017
1	sofosbuvir velpatasvir voxilaprevir drug combinationIBA 01/2017
1	trichostatin A (A 300)IBA 01/2017
1	sofosbuvir drug combination ledipasvirIBA 01/2016
1	GS-9669IBA 01/2016
1	GS-9451IBA 01/2016
1	lorcaserinIBA 01/2016
1	NucleotidesIBA 01/2016

Therapy/Procedure

37	Therapeutics 01/2019 - 10/2007
10	Liver Transplantation 01/2019 - 11/2003
6	Duration of Therapy 06/2020 - 01/2008
5	Retreatment 01/2019 - 10/2007
5	Drug Tapering 04/2014 - 10/2010
4	Platelet Transfusion (Blood Platelet Transfusions) 04/2020 - 06/2008